Re: 8-azacytidine

[Anisha Akula <aakula@FACSTAFF.WISC.EDU>]

Hi Meriel,

Is it not 5-azacytidine( in the pyridine ring of cytocynine 5th carbon atom was
replaced by nitrogen atom), an analogue of cytocynine ? Where the 8-azacytidine
is comming from???.. also refere to trade names/similar products....DHAC or
1,3,5 Triazin or  5ACH.
The very first report on the use of 5-Aza in plant TC has come from Lorz's
lab(Germany) Brown et al TAG;78: 321-328(1989). If I remember correctly they
reported no obvious use of  5 Aza in plant TC; but recent studies showed very
significant positive results..
I am also  planning to use in my maize TC expt., if you find  some thing
exciting  result please do share the results...

C. Akula,Ph.D.
Maize chromatin group
Agronomy dept. University of Wisconsin

At 06:05 PM 2/13/2001 -0500, you wrote:
>
> I've been told that 8-azacytidine may be useful in regenerating recalcitrant
> varieties. It is supposed to act by demethylating the DNA, so re-activating
> genes. Have you any advice about using it - concentrations etc?
>
> Meriel Jones
> Allium Research Group
> University of Liverpool, UK

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